The proposed project aims at evaluating the sensitivity of ihMT for probing and characterizing myelin
impairments occurring in animal model of myelin disorders. The goal will be to assess whether ihMT can depict the time course of specific myelin impairments, such as progressive demyelination followed by partial or complete remyelination and to compare ihMT metrics with other MR metrics (such a conventional MT), which are often used to follow up and study myelin pathologies as well as with myelin histology imaging. The successful candidate will have in charge the conduct of these preclinical studies, including experiment planning, animal handling, MRI sequence optimization, data acquisition, analysis and statistical comparison with reference techniques. She/He will work within the ihMT team, in interaction with computer engineers, biologists, neurologists and clinicians working in the Central Nervous System MRI research team.
In parallel, the candidate will develop his general MRI knowledge and work on the development of novel ihMT approaches (pulse sequence programming for Bruker 7T and 11.75T), aiming at improving the sensitivity and specificity of the technique for given pathologies and myelin alterations.

We are looking for a motivated candidate with a Master’s/Engineer’s degree in biomedical engineering, medical imaging, MR physics or related topic. Prior experience with MRI techniques and/or magnetization transfer would be advantageous but is not mandatory. Good writing and communication skills in English are required. The successful candidate will work in the ihMT team composed of two senior scientists and three PhD students. The duration of the project, founded by the Agence National de la Recherche, is 36 months with a salary and benefits corresponding to usual PhD program conditions.